Formulation development is the final stage in the process of development of a drug. In Formulation development various chemicals, including the active drug, are combined to obtain the final product. In this process we need to produce a drug that is stable over time and easy to use by the patient.
Formulation development include mandatory tests of whether the drug is compatible with the other substances contained in the tablet. Various factors such as polymorphism, pH, particle size and solubility, which may affect the efficacy of the drug, should be taken in account.
Drugs are stored in different packages – blisters, bottles, vials, ampoules, etc. for a long period of time. Therefore, Formulation development includes the necessity to examine whether there is any interaction between the drug and the packaging into which is stored.
Studies in the field lead to the production of some very useful wrappers such as delayed release tablets. They are prepared with an osmotically active substance, surrounded by a special membrane. While the tablet is in the alimentary tract, this combination makes it so that the drug passes through the membrane gradually and ensures the activity of the drug for longer period of time.
Formulation development is quite a complex procedure that requires extensive experience and can be awarded only to a highly specialized company. You can learn more about formulation development at the website of one of the few companies with extensive research experience in the field – UPM Pharmaceuticals. It began it’s development in 1990 as a scientific laboratory at the University of Maryland and then developed as an independent organization. The company has a modern plant for pharmaceutical production, as well as several laboratories, located in 40,000 square feet, employing professionals with great experience in pharmaceuticals.
UPM Pharmaceuticals offers high quality services for drug development, including Formulation development, research, testing endurance under different conditions and production of cGMP. UPM has also a manufacturing facility in Bristol, Tennessee (USA) located in more than 500 000 square feet. By this factory Bristol UPM can ensure manufacture of solid tablets and capsules as well as creams and salves.